Preventive role of social interaction for copyright conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas

Preventive role of social interaction for copyright conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas

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The worsening of drug abuse by drug-associated social interaction is a well-studied phenomenon.In contrast, the molecular mechanisms of the beneficial effect of social interaction, if offered as a mutually exclusive choice to drugs of abuse, are under-investigated.In a rat place preference conditioning (CPP) paradigm, four 15 min episodes of social interaction with a gender- and weight matched male early-adult conspecific inhibited copyright-induced reinstatement of copyright CPP, a model of relapse.

These protective Machine Learning-Based Fine Classification of Agricultural Crops in the Cross-Border Basin of the Heilongjiang River between China and Russia effects of social interaction were paralleled by a reduced activation, as assessed by Zif268 expression in brain areas known to play pivotal roles in drug-seeking behavior.Here we show that social interaction during extinction of copyright CPP also reduced copyright-CPP-stimulated FosB expression in the nucleus accumbens shell and core.In addition, social interaction during copyright CPP extinction increased pCREB (cAMP response element binding protein) expression in the nucleus accumbens shell REMOTE OPERATION OF THE WEST COAST AND ALASKA TSUNAMI WARNING CENTER and the cingulate cortex area 1 (Cg1).

Our results show that FosB and pCREB may be implicated in the protective effect of social interaction against copyright-induced reinstatement of CPP.Thus, social interaction, if offered in a context that is clearly distinct from the previously drug-associated one, may profoundly inhibit relapse to copyright addiction.